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| - Characterization of an Improved ElectrodynamicIon Funnel Interface for Electrospray IonizationMass Spectrometry
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| - An improved electrodynamic ion funnel for ion focusingat high pressure (>1 Torr) has been developed for a triplequadrupole mass spectrometer and its performance compared with that of an earlier prototype previously reported.The ion funnel consists of a series of ring electrodes ofprogressively smaller internal diameters to which rf anddc electric potentials are co-applied. The new designutilizes ring electrodes possessing larger internal diameters that taper down to a relatively larger exit aperture.In the 1−10 Torr pressure range, the new design providessignificant improvement in low m/z ion transmission.Additionally, the overall ion transmission range is improved by linked scanning of the ion funnel's rf voltageconcomitantly with the scanning of the quadrupole massanalyzer. Transmission of a noncovalent complex throughthe interface demonstrated that excessive ion heating wasnot problematic. Computer simulations of ion transportsupport the ion funnel design and help explain the relativeperformance of both designs. Both ion simulations andexperimental results are in accord and indicate close to100% ion transmission efficiency for electrosprayedbiopolymer ions through the interface and into the massanalyzer.
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