| Abstract
| - An on-chip electrochemical detector for micromachinedcapillary electrophoresis (CE) systems, based on sputtering a gold working electrode directly onto the capillaryoutlet, is described. The new on-chip detector preparationrequires no microfabrication or alignment procedures nora decoupling mechanism. The attractive performance ofthe integrated electrophoresis chips/amperometric detection was demonstrated for the anodic detection of neurotransmitters. The response for dopamine was linearfrom 20 to 200 μM, with a LOD of 1.0 μM and asensitivity of 52 pA/μM. Such intimate coupling of capillary electrophoresis chips and electrochemical detectionfacilitates the realization of complete integrated microanalytical devices.
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