| Abstract
| - Capillary electrochromatography using a specialty monolithic matrix was utilized in developing a rapid and highlyefficient separation of isoflavones in biological materials.Without a preconcentration technique, it is relatively easyto reach ppm−ppb concentrations of these compoundsin soy-based foods and verify them structurally using aphotodiode array detector. With on-column preconcentration, we were able to measure low-ppb levels in humanserum. Using blood samples from human volunteers,whose diet was supplemented by a soy-based product, themethod has been validated for high-throughput screeningof isoflavones in clinical studies.
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