| Abstract
| - We have successfully synthesized both enantiomers of anovel chiral ionic liquid, (R)- and (S)-[(3-chloro-2-hydroxypropyl) trimethylammonium][bis((trifluoromethyl)sulfonyl)amide] ((R)- and (S)-[CHTA]+[Tf2N]-) in opticallypure form by a simple ion exchange reaction from corresponding chloride salts that are commercially available.In addition to the ease of preparation, this chiral IL hasrelatively high thermal stability (up to 300 °C), is liquidat room temperature (glass transition temperature of−58.4 °C), and exhibits strong enantiomeric recognition.The high solubility power and strong enantiomeric recognition ability make it possible to use this chiral IL tosolubilize an analyte and to induce diastereomeric interactions for the determination of enantiomeric purity. Infact, we have successfully developed a novel methodbased on the near-infrared technique with this chiral ILserving both as solvent and as a chiral selector for thedetermination of enantiomeric purity. Enantiomeric compositions of a variety of pharmaceutical products andamino acids with different shape, size, and functionalgroups can be sensitively (milligram concentration) andaccurately (enantiomeric excess as low as 0.6%) determined by use of this method.
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