| Attributs | Valeurs |
|---|
| type
| |
| Is Part Of
| |
| Subject
| |
| Title
| - On-Chip Surface-Based Detection with NanoholeArrays
|
| has manifestation of work
| |
| related by
| |
| Author
| |
| Abstract
| - A microfluidic device with integrated surface plasmonresonance (SPR) chemical and biological sensors basedon arrays of nanoholes in gold films is demonstrated.Widespread use of SPR for surface analysis in laboratorieshas not translated to microfluidic analytical chip platforms, in part due to challenges associated with scalingdown the optics and the surface area required for commonreflection mode operation. The resonant enhancement oflight transmission through subwavelength apertures in ametallic film suggests the use of nanohole arrays asminiaturized SPR-based sensing elements. The devicepresented here takes advantage of the unique propertiesof nanohole arrays: surface-based sensitivity; transmission mode operation; a relatively small footprint; andrepeatability. Proof-of-concept measurements performedon-chip indicated a response to small changes in refractiveindex at the array surfaces. A sensitivity of 333 nm perrefractive index unit was demonstrated with the integrateddevice. The device was also applied to detect spatialmicrofluidic concentration gradients and to monitor abiochemical affinity process involving the biotin−streptavidin system. Results indicate the efficacy of nanoholearrays as surface plasmon-based sensing elements in amicrofluidic platform, adding unique surface-sensitivediagnostic capabilities to the existing suite of microfluidic-based analytical tools.
|
| article type
| |
| is part of this journal
| |
