| Abstract
| - Nonviral gene delivery is limited to a large extent by the cationic nature of most of the chemical vector. We haveshown that lipopolythioureas interact with DNA. However, lipopolythioureas were not very efficient at transfectingcells, probably due to reduced interaction between the noncationic synthetic lipid and the cell membrane. Here,we report that liposomes made from a new thiourea lipid, DPPC, and a lipid bearing an RGD ligand allowed veryefficient entry of the lipopolythioureas into integrin αvβ3 expressing cells. In addition, we show that a stableinteraction between DNA and lipopolythiourea could be obtain with two thiourea groups. Moreover, the additionof a hydrophilic terminus improves the formulation of these new DNA binding agents.
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