| Abstract
| - Taxol, an anticancer substance, was adsorbed into FSM-type mesoporous silicas with thepore sizes larger than 1.8 nm, while it was not adsorbed into the channels with the poresize less than 1.6 nm, indicating that mesoporous silicas have a molecular sieving propertyfor relatively large molecules. The adsorption behavior of Taxol depended on the solvents;Taxol was not adsorbed into mesoporous silicas when methanol or acetone was used butwas adsorbed when dichloromethane or toluene was used. The adsorption behavior of Taxolis discussed on the basis of the solubility parameters of the solvents. The proton-acceptorsolubility parameter (δa) is a predominant factor in this liquid−solid partition system. Theadsorption−desorption of an extract from yew needles was performed using the mesoporoussilica and several elution solvents. In the adsorption, many components including Taxolwere adsorbed into mesoporous silica. When the desorption of the extract componentsadsorbed into the mesoporous silica was performed with a mixture of methanol and waterwith varied ratios, the targeted molecule, Taxol, with a few addition of components wasseparated from the adsorbed components. This adsorption−desorption behavior waselucidated by the solubility parameter (δ) as well as δa.
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