| Abstract
| - Organic modification with aminopropyl group of two MCM-41 materials having differentpore sizes (obtained from trimethylalkylammonium surfactants with different chain sizes(16 and 12 carbon atoms)) has been carried out in order to control the delivery rate ofibuprofen from the siliceous matrix. This functionalization was performed by two differentmethods: the as-synthesized MCM-41 sample was treated with aminopropyltrimethoxysilane(method a), and the MCM-41 was first calcined and then funtionalized by reaction withaminopropyltrimethoxysilane (method b). The amount of ibuprofen adsorbed from hexanesolution is lower for the C12 derived materials. A slower delivery rate has been observed formethod b, whereas a minor influence of the pore size on the delivery rate has been found.
- It has been possible to control the drug delivery rate of two MCM-41 materials by organic modification with an aminopropyl group. This functionalization was carried out by two different methods leading to different results. The stronger interaction of the analgesic ibuprofen with the amino groups present in the pore walls, compared to that existing with silanols, leads to a decrease of the delivery rate.
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