| Abstract
| - Materials based on ceramic−polymer−gentamicine blends with potential application asprefabricated bone blocks and drug delivery systems have been synthesized. Three series ofmaterials have been prepared with varying composition of the ceramic fraction. The ceramiccomponent of series S1 contains only hydroxiapatite (HA), series S2 contains HA and 2.7%sol−gel glass, and series S3 contains 29% glass. Series S3 develops an apatite-like phase onthe surface when soaked in simulated body fluid (SBF). Series S2 undergoes surface changes,but the development of an apatite-like phase does not occur. Finally, series S1 does notexhibit significant changes at the surface. Materials with 29% glass show an importantsurface area reduction during the first 24 h due to the formation of an amorphous calciumphosphate before the OHAp crystallization. This surface reduction leads to a retardation ofthe drug release during this period compared to the samples with no glass or 2.7% glass.The results presented in this work point out that when synthesizing bioactive materials tobe used as drug delivery systems, the important surface modifications must be consideredfor the drug release kinetics.
- The bioactive behavior and liberation of gentamicine from ceramic/polymer/antibiotic mixed materials is influenced by the sol−gel glass component. The sample with the highest content of glass (S3) develops a microporous silica-rich layer that modifies the texture of the surface (inset) and, consequently, affects the drug release kinetics.
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