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| - Nitric Oxide-Releasing Xerogel Microarrays Prepared withSurface-Tailored Poly(dimethylsiloxane) Templates
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| - Surface graft polymerization with poly(ethylene glycol) acrylate is reported as an effective method formodifying the surface of poly(dimethylsiloxane) array templates thus enabling the preparation of nitricoxide (NO)-releasing xerogel micropatterns. The surface wettability of PEGA-grafted templates wassufficient to overcome the flow resistance of ethyltrimethoxysilane (ETMOS) sol solutions and allowthe formation of xerogel microarrays via capillary action of sol through the template channels. Due tothe combined versatility of both sol−gel chemistry and micropatterning, substrates were modified witha range of aminosilane-doped xerogel microarrays with variable NO release properties. Several parameterswere studied including (1) NO surface flux as a function of type and concentration of aminosilane NO-donor precursor; (2) micropattern dimensions for maximizing surface flux and duration of NO release;and (3) the effect of microstructure separation on localized NO surface concentration as determined witha NO-selective ultramicroelectrode sensor. Xerogel microarrays were characterized by initial NO surfacefluxes ranging from 3.9 ± 0.5 to 73.6 ± 5.7 pmol·cm-2·s-1. Although the NO surface flux subsided withtime as the finite reservoir within the xerogel became depleted, the duration of measurable NO releasewas double that of previously reported MTMOS arrays. Thus, NO-releasing aminosilane-modified ETMOSarrays may represent a promising strategy for further improving the in vivo biocompatibility of implantablesensors.
- Poly(ethylene glycol) acrylate is grafted onto the surface of poly(dimethylsiloxane) array templates via ultraviolet light initiated surface polymerization. The grafted template is then used to prepare aminosilane-modified ethyltrimethoxysilane xerogel microarrays with tunable nitric oxide release profiles.
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