| Abstract
| - A generalized silica-coating procedure in toluene has been developed for various hydrophobic 2−20 nm nanoparticles, such as Au, Ag, Fe3O4, and ZnS−CdSe. The silica-coated particles are 10−30 nm in size, water-soluble, buffer-stable, and have a positive or nagative surface charge depending on their surface functional group and solution pH.
- Synthetic methods for high-quality near-monodispersed nanoparticles of metals, metal oxides, andquantum dots in organic solvents are well-developed, but their applications are restricted due to the lackof water solubility and tailored surface chemistry. In this work, we report the silica-coating procedurefor various hydrophobic nanoparticles, including Au, Ag, Fe3O4, and ZnS−CdSe to derive water-solubleand functionalized nanoparticles. We have developed a silica-coating method in toluene using commerciallyavailable silanes. This approach is applicable to hydrophobic nanoparticles in the size range of 2−20nm. Silica-coated nanoparticles are 10−30 nm in size, water-soluble, buffer-stable, and have a positiveor negative surface charge depending on the surface functional group and solution pH. The coatedparticles have primary amine groups on the outer surface and are further functionalized with biotin andantibody.
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