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| Title
| - Controlling Drug Release of Sol−Gel Encapsulated Persantin and Propranolol by Surface Interactions
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| Abstract
| - Two drug molecules, Propranolol and Persantin, have been encapsulated by a sol−gel process in an organic−inorganic hybrid matrix by in situ self-assembly. The synthesis parameter, compositions, and pH values in the sol−gel synthesis control the dissolution of the drugs and pore size and distribution of the gels. The noncovalent host−guest interaction can be tailored to control the release kinetics by appropriate choice of an organic group in the hybrid matrix. The surface interactions of the drug as well as the diffusion barriers of the matrix control the release kinetics of the drug molecules. The higher surface area of spray dried microparticles with molecularly dispersed drug molecules enhances the dissolution process.
- Spray drying (SD) and evaporation induced self-assembly (EISA) were two alternative processing methods to encapsulate drug molecules in an organic-inorganic hybrid material. The noncovalent host-guest interactions can be tailored to control the release kinetics based on characteristic pH regimes and specific surface modifications. The higher surface area of spray dried microparticles with molecularly dispersed drug molecules enhances the dissolution process.
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| - Drug Release of Encapsulated Persantin and Propranolol
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