| Abstract
| - The reaction between aryl aldehydes, the macrocyclic ligand 6-methyl-1,4,8,11-tetraazacyclotetradecane-6-amine(L1), and NaBH3CN produces the corresponding benzyl-substituted ligands in good yield. Copper(II) complexesof the ligands derived from salicylaldehyde (L2), p-hydroxybenzaldehyde (L4), and p-carboxybenzaldehyde (L5)were structurally characterized: [CuL2](ClO4)2·3H2O (monoclinic, P21/c, a = 11.915(6) Å, b = 13.861(2) Å, c= 17.065(8) Å, β = 102.14(2)°, Z = 4); [CuL4](ClO4)2 (monoclinic, P21/n, a = 9.550(3) Å, b = 17.977(2) Å,c = 14.612(4) Å, β 96.76(1)°, Z = 4), and [CuL4](ClO4)2 (monoclinic, P21/n, a = 9.286(2) Å, b = 11.294(1) Å,c = 23.609(8) Å, β 93.68(1)°, Z = 4). Conjugation of several CuII complexes to a protein (bovine serum albumin)has been pursued with a view to the application of these macrocycles as bifunctional chelating agents inradioimmunotherapy.
- Several C-substituted tetraazamacrocyclic ligands have been synthesized and characterized as their copper(II) complexes. X-ray crystal structural analyses of three of these complexes are presented, and some of these have been attached to the protein bovine serum albumin.
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