| Abstract
| - A novel hexadentate ligand based on dipyridylamine forms either mono- or trinuclear Pt(II) complexes. The platinum tertiary complexes with the ligand and CBDCA are able to bind strongly to calf thymus DNA, and the CBDCA group can be readily displaced by thiourea.
- A novel hexadentate ligand, N,N,N‘,N‘,N‘ ‘,N‘ ‘-hexa(2-pyridyl)-1,3,5-tris(aminomethyl)benzene (L), was designed and synthesized. TheX-ray structure analysis reveals that the three dipyridylamine (DPA)groups of L are almost perpendicular to the central trimethylenebenzene, and two of them are spacially close to each otherwhile the third one is further apart. The trinuclear Pt(II) complexes[Pt3LCl6] (1) and [Pt3L(CBDCA)3] (2) (where CBDCA representscyclobutane dicarboxylic acid) were prepared and fully characterizedby IR, NMR, and ESMS spectroscopy. A mononuclear complex,[PtL(CBDCA)] (3), was also prepared and structurally characterized,which suggests that controlled formation of mono-, di-, andtrinuclear complexes with L is possible. Spectroscopic data showedthat complexes 2 and 3 are able to bind to calf thymus DNA andtheir CBDCA group can be readily replaced by thiourea.
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