| Abstract
| - Gold complexes of the type [(AuPEt3)2xspa] were prepared by reacting AuPEt3Cl in basic media with the 3-(aryl)-2-sulfanylpropenoic acids H2xspa [x = p, Clp, -o-mp, -p-mp, -o-hp, -p-hp, diBr-o-hp, f, t, -o-py; p = 3-phenyl, Clp = 3-(2-chlorophenyl)-, -o-mp = 3-(2-methoxyphenyl)-, -p-mp = 3-(4-methoxyphenyl)-, -o-hp = 3-(2-hydroxyphenyl)-, -p-hp = 3-(4-hydroxyphenyl)-, diBr-o-hp = 3-(3,5- dibromo-2-hydroxyphenyl)-, f = 3-(2-furyl)-, t = 3-(2-thienyl)-, -o-py = 3-(2-pyridyl); spa = 2-sulfanylpropenoato], and 2-cyclopentylidene-2-sulfanylacetic acid (H2cpa). The complexes were characterized by spectroscopic methods (IR, 1H, 13C and 31P NMR) and mass spectrometry, and the complexes [(AuPEt3)2pspa]·3H2O, [(AuPEt3)2-p-hpspa]·3H2O, [(AuPEt3)2tspa)]·3H2O, and [(AuPEt3)2-o-hpspa] by X-ray diffractometry. The crystals of the first three complexes contain (H2O)6 clusters hydrogen bonded to [(AuPEt3)2xspa]2 dimer units, whereas in the -o-hpspa derivative the hydrogen bonds are between the monomer [(AuPEt3)2-o-hpspa] units. The antiinflammatory activity of the complexes against plantar edema induced by carrageenan in rats is generally significant, with the values for the o-hpspa and tspa derivatives being particularly high.
- The reaction of 3-(aryl)-2-sulfanylpropenoic acids (H2xspa) with triethylphosphinegold(I) chloride in basic media afforded complexes of the type [(AuPEt3)2xspa]. The crystals of some complexes contain (H2O)6 clusters hydrogen bonded to [(AuPEt3)2xspa]2 dimer units. The antiinflammatory activity of the complexes against plantar edema induced by carrageenan in rats is in general significant, and in some cases display very high percentages of reduction of the inflammation.
|
