| Abstract
| - The total synthesis of the title compound has been accomplished. Among the key steps were (i) aconjugate additionRobinson annulation-type sequence (see 4), (ii) intramolecular carbomercuration (see 3),(iii) a reduction−ketonization sequence (see 25), (iv) cycloetherification of an unactivated methylene group(see 28), and reductive amination (see 1). A highly preliminary SAR profile suggests that the functional cytotoxicpharmacophore of hispidospermidin involved a presentation of spermidine derivative 36 via linkage to a ball-like hydrophobic cage to its target.
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