We report a catalytic asymmetric reaction process that involves the use of solid-phase reagents andcatalysts that constitute the packing of a series of “reaction columns”. This process was applied to the catalyticasymmetric synthesis of β-lactams, to yield pure products with excellent enantio- and diastereoselectivity. Wehave identified several advantages to conducting chemical reactions on sequential columns, including ease ofcatalyst and reagent recovery and simplified purification steps that preclude the need for chromatography.