Documentation scienceplus.abes.fr version Bêta

À propos de : Total Synthesis and Stereochemical Assignment of the Salicylate AntitumorMacrolide Lobatamide C        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Total Synthesis and Stereochemical Assignment of the Salicylate AntitumorMacrolide Lobatamide C
has manifestation of work
related by
Author
Abstract
  • The total synthesis and stereochemical assignment of the potent antitumor macrolide lobatamide C is reported. The synthesis involves Cu(I)-mediated enamide formation and Na2CO3-mediated esterification of a β-hydroxy acid and a salicylate cyanomethyl ester. Macrolactonization was accomplished using a Mitsunobu protocol. The stereochemical assignment of lobatamide C was achieved by Mosher ester analysis and comparison with prepared stereoisomers.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata