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À propos de : A de Novo Enantioselective Total Synthesis of (−)-Laulimalide        

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  • A de Novo Enantioselective Total Synthesis of (−)-Laulimalide
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  • An enantioselective total synthesis of the naturally occurring anticancer agent (−)-laulimalide is described. The synthesis is characterized by extensive use of new reaction methodologies based on catalytic asymmetric acyl halide−aldehyde cyclocondensation (AAC) reactions and transformations of the derived enantioenriched β-lactones. The synthesis also incorporates a unique allenylstannane glycal acetate alkylation and chemoselective ring-closing metathesis reaction.
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