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À propos de : Efficient Enantioselective Synthesis of Functionalized Tetrahydropyrans byRu-Catalyzed Asymmetric Ring-Opening Metathesis/Cross-Metathesis(AROM/CM)        

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  • Efficient Enantioselective Synthesis of Functionalized Tetrahydropyrans byRu-Catalyzed Asymmetric Ring-Opening Metathesis/Cross-Metathesis(AROM/CM)
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  • An efficient method for enantioselective synthesis of highly functionalized pyrans (up to 98% ee) through Ru-catalyzed asymmetric ring-opening metathesis/cross-metathesis is described. Reactions are promoted by a recyclable chiral Ru−chloride or a new chiral Ru−iodide complex; the latter catalyst is less efficient but gives rise to significantly higher levels of enantioselectivity. Catalytic reactions can be performed in undistilled solvent and with a wide range of substrates, including those that contain secondary and tertiary alcohols. Representative regioselective functionalizations that highlight the utility of the catalytic method are also presented.
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