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À propos de : Efficient Synthesis of Optically Active Atropisomeric Anilides throughCatalytic Asymmetric N-Arylation Reaction        

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  • Efficient Synthesis of Optically Active Atropisomeric Anilides throughCatalytic Asymmetric N-Arylation Reaction
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  • In the presence of (R)-DTBM-SEGPHOS-Pd(OAc)2 catalyst, N-arylation of ortho-tert-butyl-NH-anilides with 4-nitroiodobenzene proceeds with high enantioselectivity (89−95% ee) to give optically active atropisomeric anilides possessing N−C chiral axis. Furthermore, the intramolecular version of the present catalytic asymmetric N-arylation gave atropisomeric lactams with high optical purity (94−96% ee).
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