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| Title
| - Guidelines in Implementing EnantioselectiveIndicator-Displacement Assays for α-Hydroxycarboxylatesand Diols
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| Abstract
| - Enantioselective association events between boronic acid receptors and bifunctional substratessuch as α-hydroxycarboxylates and vicinal diols were exploited to develop enantioselective indicator-displacement assays. It was found that the sensitivity of the assay could be tuned by using either colorimetricor fluorescent indicators. Mathematical principles were established for concurrent determination ofconcentration and enantiomeric excess (ee) of a chiral analyte, which has been a challenge to the high-throughput analysis of chiral samples. Furthermore, experimental protocols were optimized to maximizethe chiral resolution of the assay and to improve the accuracy of the ee measurements.
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