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| - PEG- and Peptide-Grafted Aliphatic Polyesters by ClickChemistry
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| - Novel aliphatic polyesters with pendent acetylene groups were prepared by controlled ring-openingpolymerization and subsequently used for grafting poly(ethylene glycol) and oligopeptide moieties by theCu(I)-catalyzed addition of azides and alkynes, a type of “click” chemistry. These aliphatic polyesters possessan acetylene graft density that can be tailored by ring-opening copolymerization of α-propargyl-δ-valerolactone (1) with ε-caprolactone. Since the mild conditions associated with the click reaction are shownto be compatible with the polyester backbone, this method is a generally useful means for grafting numeroustypes of functionality onto aliphatic polyesters. The amphiphilic graft polyesters prepared in this study areshown to be biocompatible by in vitro cytotoxicity evaluation, suggesting their suitability for a range ofbiomaterial applications.
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