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À propos de : A Potent Transactivation Domain Mimic with Activity in Living Cells        

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  • A Potent Transactivation Domain Mimic with Activity in Living Cells
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  • Transcriptional coactivator-binding peptoids were isolated from a large combinatorial library. One of these molecules is shown to function as a potent activation domain surrogate in mammalian cells. Up to a 900-fold increase in expression of a Gal4-responsive reporter gene is observed when a steroid conjugate of the peptoid is incubated with HeLa cells expressing a Gal4 DNA-binding domain (DBD)−glucocorticoid receptor ligand-binding domain (GRLBD) fusion protein.
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