About: Light Regulation of Aptamer Activity: An Anti-Thrombin Aptamer with CagedThymidine Nucleobases

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Attributs	Valeurs
type	work Article
Is Part Of	http://hub.abes.fr/acs/periodical/jacsat/2005/volume_127/issue_3/w
Subject	Communication
Title	Light Regulation of Aptamer Activity: An Anti-Thrombin Aptamer with CagedThymidine Nucleobases
has manifestation of work	http://hub.abes.fr/acs/periodical/jacsat/2005/volume_127/issue_3/101021ja043285e/m/web http://hub.abes.fr/acs/periodical/jacsat/2005/volume_127/issue_3/101021ja043285e/m/print
related by	http://hub.abes.fr/acs/periodical/jacsat/2005/volume_127/issue_3/101021ja043285e/authorship/1 http://hub.abes.fr/acs/periodical/jacsat/2005/volume_127/issue_3/101021ja043285e/authorship/2
Author	Mayer Günter Heckel Alexander
Abstract	“Caged” derivatives of a 15 nucleotide ssDNA anti-thrombin aptamer have been synthesized in which thymidine nucleotides are modified with photolabile protecting groups. One caged thymidine in a key location is enough to completely mask the aptamer's function in respect to their affinity for thrombin and their inhibition of the blood clotting cascade. With light (366 nm) the caging group can be removed, yielding the unmodified active aptamer.
article type	rapid-communication
is part of this journal	Journal of the American Chemical Society

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