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À propos de : Quantum-Dot/Aptamer-Based Ultrasensitive Multi-Analyte ElectrochemicalBiosensor        

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  • Quantum-Dot/Aptamer-Based Ultrasensitive Multi-Analyte ElectrochemicalBiosensor
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  • The coupling of aptamers with the coding and amplification features of inorganic nanocrystals is shown for the first time to offer a highly sensitive and selective simultaneous bioelectronic detection of several protein targets. This is accomplished in a single-step displacement assay in connection to a self-assembled monolayer of several thiolated aptamers conjugated to proteins carrying different inorganic nanocrystals. Electrochemical stripping detection of the nondisplaced nanocrystal tracers results in a remarkably low (attomole) detection limit, that is, significantly lower than those of existing aptamer biosensors. The new device offers great promise for measuring a large panel of disease markers present at ultralow levels during early stages of the disease progress.
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