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À propos de : Multiple-Timescale Dynamics of Side-Chain Carboxyl and Carbonyl Groups in Proteins by 13C Nuclear Spin Relaxation        

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  • Multiple-Timescale Dynamics of Side-Chain Carboxyl and Carbonyl Groups in Proteins by 13C Nuclear Spin Relaxation
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  • Side-chain carboxyl and carbonyl groups play a major role in protein interactions and enzyme catalysis. A series of 13C relaxation experiments is introduced to study the dynamics of carboxyl and carbonyl groups in protein side chains on both fast (sub-ns) and slower (μs−ms) time scales. This approach is illustrated on the protein calbindin D9k. Fast dynamics features correlate with hydrogen- and ion-binding patterns. We also identify chemical dynamics on μs time scales in solvent-exposed carboxyl groups, most probably due to exchange between the carboxylate and carboxylic acid forms.
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