| Abstract
| - The effects of glucosinolates (GLs) (sinigrin, gluconapin, progoitrin,epi-progoitrin, sinalbin,glucotropaeolin, glucoerucin, glucocheirolin, and glucoraphenin) andtheir enzymatic hydrolysis-derived products (EHDPs) have been studied in controlling theproliferation of cancer cell lines.The results of this study indicate the following: (i) neithermyrosinase nor intact GLs have anyeffect on tumor cell growth when used up to 36 U/mL and 500 μM,respectively; (ii) all EHDPsshow a clear inhibition of human erythroleukemic K562 cellproliferative growth, which isparticularly evident for EHDPs from sinigrin, glucotropaeolin,glucoerucin, and glucocheirolin (IC50< 20 μM); (iii) the EHDP production by in situ orpre-mix procedures gives rather similarantiproliferative effects; and finally, (iv) the EHDPs fromglucoraphenin are active toward severalother tumor cells, viz. FL (murine erythroleukemic cells), Jurkat(human T-lymphoid cells), HeLa(human cervix carcinoma cells), H9 (human T-lymphoid cells), andH3-T1-1 cells (obtained bytransfection of HeLa with a LTR-HIV-1-CAT plasmid). Keywords: Crucifers; glucosinolates; isothiocyanates; myrosinase; antitumoractivity
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