| Abstract
| - Solutions of supercritical CO2 modified with 5, 10, and 20%methanol, ethanol, acetone, andacetonitrile were compared for the extraction of sulfonamides fromfortified chicken liver. The resultsshowed both 20% acetone-modified CO2 and 20%acetonitrile-modified CO2 were capable ofquantitatively extracting sulfamethazine, sulfaquinoxaline, andsulfadimethoxine, whereas 20%ethanol- and 20% methanol-modified CO2 were found to beless efficient. Acetonitrile-modified CO2however, produced fewer chromatographic interferences than acetone,making quantitation easier.Sub-ppm levels of the three analytes were shown to bequantitatively extracted from chicken liverwith 20% acetonitrile modifier. Also, quantitative recovery wasobtained with spiked beef liversamples employing 20% acetone modifier, and greater than 90% recoverywas obtained for two ofthe three with 20% acetonitrile-modified CO2, while either20% acetone- or 20% acetonitrile-modifiedCO2 was found to yield quantitative recovery from egg yolk.In contrast to conventional samplepreparation procedures no sample cleanup prior to quantitative analysiswas required. Keywords: SFE; sulfonamides; extraction; supercritical fluid; chicken;beef; egg
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