| Abstract
| - We investigated the effects of erythritol on rats with streptozotocin- (STZ-) induced diabetes mellitus.Oral administration of erythritol [100, 200, or 400 mg (kg body weight)-1 day-1 for 10 days] to ratswith STZ-induced diabetes resulted in significant decreases in the glucose levels of serum, liver, andkidney. Erythritol also reduced the elevated serum 5-hydroxymethylfurfural level that is glycosylatedwith protein as an indicator of oxidative stress. In addition, thiobarbituric acid-reactive substancelevels of serum and liver and kidney mitochondria were dose-dependently lower in the erythritol-treated groups than in the control diabetic group. Furthermore, the serum creatinine level was reducedby oral administration of erythritol in a dose-dependent manner. These results suggest that erythritolaffects glucose metabolism and reduces lipid peroxidation, thereby improving the damage causedby oxidative stress involved in the pathogenesis of diabetes. Keywords: Erythritol; diabetes; glucose; 5-hydroxymethylfurfural; thiobarbituric acid-reactive substance; creatinine; rat
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