| Abstract
| - Polychlorodibenzo-para-dioxins (PCDDs) and Polychlorodibenzofurans (PCDFs) are ubiquitous inthe environment. They are mainly formed as unwanted byproducts during various chemical, industrial,and combustion processes. Thus, these pollutants can be found in the food chain. The aim of thisexperiment was to study the transfer of PCDD/Fs from spiked milk to arterial blood in pigs, which areconsidered as valid models for humans. Pigs were fed with 900 mL of milk spiked with a mixture of17 dioxins. The levels of PCDD/Fs in the serum extracts were determined using HRGC/HRMS priorto consumption of the milk, and at 3, 5, and 7 h after milk ingestion. Concentrations of PCDD/Fs inarterial plasma increased from 3 h to 5 h and decreased at 7 h. At time point 5 h, concentrationswere found between 500 and 10 000 pg g-1 fat. The transfer ratio ≪ plasma fat/milk fat ≫ was usuallyfound between 0.7 and 3%. Related to the different milk concentrations, results of this study indicatea similar behavior of the studied molecules. Keywords: Dioxins; milk; blood; pigs
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