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À propos de : Molecular Design Based on 3D-Pharmacophore. Application to 5-HT SubtypesReceptors        

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  • Molecular Design Based on 3D-Pharmacophore. Application to 5-HT SubtypesReceptors
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  • A first definition of a pharmacophore for the serotonin reuptake inhibitors was carried out by consideringa three-dimensional model which correlates the chemical structures of series of reuptake inhibitors withtheir biological affinities. A molecular design was described by analyzing two different 3D serotoninpharmacophores. This successful approach enabled us to consider the design of new serotonin ligands bythe same method.
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