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À propos de : On the Parametrization of the Toxicity of Organic Chemicals to Tetrahymena pyriformis.The Problem of Establishing a Uniform Activity        

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  • On the Parametrization of the Toxicity of Organic Chemicals to Tetrahymena pyriformis.The Problem of Establishing a Uniform Activity
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  • In this report we illustrate the importance of making an effort to ensure that all of the dependent variablesin a QSAR are associated with one mechanism of action. If this cannot be established, it will not be possibleto compare the QSAR with others acting on different biological systems. That is, such information cannotbe used to develop a science of chemical−biological interactions. A study of the action of a large set ofphenols acting on Tetrahymena pyriformis made by Cronin and Schultz is analyzed to illustrate the problem.
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