| Abstract
| - The effects produced by nine dihydro-β-agarofuran sesquiterpenes isolated from Crossopetalumtonduzii (1−8) and Maytenus macrocarpa (9) (Celastraceae) on the reversion of the resistantphenotype on a multidrug-resistant Leishmania line and their binding to recombinantC-terminal nucleotide-binding domain of Leishmania P-glycoprotein-like transporter werestudied. The structures of the new compounds (1−5) were elucidated by spectroscopic methods,including 1H−13C heteronuclear correlation (HMQC), long-range correlation spectra withinversal detection (HMBC), ROESY experiments, and chemical correlations. The absoluteconfiguration of one of them (1) was determined by CD studies. The structure−activityrelationship is discussed.
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