| Abstract
| - Human 5‘-deoxy-5‘-methylthioadenosine phosphorylase (MTAP) participates in the purine salvage pathway togenerate adenine and methylthioribose-1-phosphate, which inturn is converted into adenine nucleotides and methionine.Hence, inhibition of MTA phosphorylase may be an effectivetarget in the design of potential antiproliferative agents.Presented herein is the synthesis of 2-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-methylsulfanylmethylpyrrolidin-3,4-diol (1), a potent inhibitor of MTAP.
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