| Abstract
| - By targeting dual active sites of AChE, a series ofbis-huperzine B analogues with various lengths of the tetherwere designed, synthesized, and tested for their inhibition andselectivity. The most potent bis-huperzine B (5g) exhibited3900-fold increase in AChE inhibition and 930-fold greater inselectivity for AChE vs BuChE than its parent huperzine B.
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