| Abstract
| - Newly synthesized mono-, di-, and triphosphate of2-alkynyl adenosines showed very different behavior in humanplatelet P2Y receptor models, according to the different alkynylchains. In fact, 2-hexynyladenosine di- (5) and triphosphate(7) induced platelet shape change and aggregation and inhibited PGE1-induced increase in platelet cyclic AMP. On thecontrary, the corresponding 2-phenylethynyladenosine di- (6)and triphosphate (8) did not induce platelet shape change oraggregation, but inhibited platelet aggregation induced byADP.
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