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Attributs	Valeurs
type	work Issue
Is Part Of	http://hub.abes.fr/acs/periodical/jmcmar/2006/volume_49
has manifestation of work	http://hub.abes.fr/acs/periodical/jmcmar/2006/volume_49/issue_23/m/print http://hub.abes.fr/acs/periodical/jmcmar/2006/volume_49/issue_23/m/web
Date Copyrighted	2006
Rights	Copyright © 2006 American Chemical Society
issue	23
Rights Holder	American Chemical Society
is Is Part Of of	Presentation of a Structurally Diverse and Commercially Available Drug Data Set forCorrelation and Benchmarking Studies Common Pharmacophores for Uncharged Human Ether-a-go-go-Related Gene (hERG) Blockers Benchmarking Sets for Molecular Docking Flavonoid Dimers as Bivalent Modulators for P-Glycoprotein-Based Multidrug Resistance: Synthetic Apigenin Homodimers Linked with Defined-Length Poly(ethylene glycol) SpacersIncrease Drug Retention and Enhance Chemosensitivity in Resistant Cancer Cells Synthesis, Radiosynthesis, and Biological Evaluation of Carbon-11 Labeled2β-Carbomethoxy-3β-(3‘-((Z)-2-haloethenyl)phenyl)nortropanes: Candidate Radioligands for inVivo Imaging of the Serotonin Transporter with Positron Emission Tomography Effects of Substitution on 9-(3-Bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4-azacyclopenta[b]naphthalene-1,8-dione, a Dihydropyridine ATP-Sensitive Potassium ChannelOpener Thyroid Receptor Ligands. 6. A High Affinity“Direct Antagonist” Selective for the ThyroidHormone Receptor 4,5-Dihydroxypyrimidine Carboxamides andN-Alkyl-5-hydroxypyrimidinone CarboxamidesAre Potent, Selective HIV Integrase Inhibitorswith Good Pharmacokinetic Profiles inPreclinical Species Antitumor Activity of Substituted E-3-(3,4,5-Trimethoxybenzylidene)-1,3-dihydroindol-2-ones Improved Therapeutic Efficacy of Doxorubicin through Conjugation with a Novel Peptide DrugDelivery Technology (Vectocell) Crystal Structures of Human Adenosine Kinase Inhibitor Complexes Reveal Two DistinctBinding Modes Matched Molecular Pairs as a Guide in the Optimization of Pharmaceutical Properties; a Studyof Aqueous Solubility, Plasma Protein Binding and Oral Exposure Three-Dimensional Quantitative Structure−Activity Relationships of ATP-Sensitive Potassium(KATP) Channel Openers Belonging to the 3-Alkylamino-4H-1,2,4-benzo- and3-Alkylamino-4H-1,2,4-pyridothiadiazine 1,1-Dioxide Families Multitarget-Directed Drug Design Strategy: A Novel Molecule Designed To Block EpidermalGrowth Factor Receptor (EGFR) andTo Exert Proapoptotic Effects Extremely Potent Orally ActiveBenzo[g]quinoline Analogue of the Dopaminergic Prodrug: 1-Propyl-trans-2,3,4,4a,5,7,8,9,10,10a-decahydro-1H-benzo-[g]quinolin-6-one. Bisphosphonate Inhibition of Phosphoglycerate Kinase: Quantitative Structure−ActivityRelationship and Pharmacophore Modeling Investigation Structure−Activity Relationships for Cytotoxic Ruthenium(II) Arene Complexes ContainingN,N-, N,O-, and O,O-Chelating Ligands Small-Molecule Inhibitors of Histone Acetyltransferase Activity: Identification and BiologicalProperties Further Insight into the DNA Recognition Mechanism of Trabectedin from the DifferentialAffinity of Its Demethylated Analogue Ecteinascidin ET729 for the Triplet DNA Binding SiteCGA Bridging Chemical and Biological Space: “Target Fishing” Using 2D and 3D MolecularDescriptors Binding of 13-Amidohuprines to Acetylcholinesterase: Exploring the Ligand-InducedConformational Change of the Gly117-Gly118 Peptide Bond in the Oxyanion Hole 7-Aroyl-aminoindoline-1-sulfonamides as a NovelClass of Potent Antitubulin Agents 5-Pyrrolidinylsulfonyl Isatins as a Potential Tool for the Molecular Imaging of Caspases inApoptosis In Silico-Guided Target Identification of a Scaffold-Focused Library: 1,3,5-Triazepan-2,6-diones as Novel Phospholipase A2 Inhibitors Discovery of S-(2-Guanidylethyl)-isothiourea(VUF 8430) as a Potent Nonimidazole HistamineH4 Receptor Agonist Do Structurally Similar Ligands Bind in a Similar Fashion? Receptor-Based Pharmacophores for Serotonin 5-HT7R AntagonistsImplications to Selectivity trans-2,3-Dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: Synthesis,Resolution, and Preliminary Pharmacological Characterization of a New Dopamine D1Receptor Full Agonist Identification of Small Molecule Agonists of theOrphan Nuclear Receptors Liver ReceptorHomolog-1 and Steroidogenic Factor-1 Comparison of Proposed Putative Active Conformations of Myelin Basic Protein Epitope 87−99Linear Altered Peptide Ligands by Spectroscopic and Modelling Studies: The Role of Positions91 and 96 in T-Cell Receptor Activation Dirhodium(II,II) Complexes: Molecular Characteristics that Affect in Vitro Activity Novel Selective Orally Active CRTH2 Antagonistsfor Allergic Inflammation Developed from inSilico Derived Hits Synthesis from Caffeine of a Mixed N-Heterocyclic Carbene−Silver Acetate Complex Activeagainst Resistant Respiratory Pathogens 2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studiestoward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide(Dasatinib, BMS-354825) as a Potent pan-Src Kinase Inhibitor Design, Synthesis, and Biological Evaluation of New Cyclic Melanotropin Peptide AnaloguesSelective for the Human Melanocortin-4 Receptor From Natural Products to Bioorganic Chemistry. What's Next?

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