| Abstract
| - In this study we report the design, synthesis, and activity against bovine viral diarrhea virus (BVDV) of anovel series of acridone derivatives. BVDV is responsible for major losses in cattle. The virus is alsoconsidered to be a valuable surrogate for the hepatitis C virus (HCV) in antiviral drug studies. Some of thesynthesized acridones elicited selective anti-BVDV activity with EC50 values ranging from 0.4 to 4 μg/mLand were not cytotoxic at concentrations that were 25- to 200-fold higher (CC50>100 μg/mL). It wasproven that the most potent acridone derivative 10 was able to not only protect cells from virus-inducedcytopathic effect but also reduce the production of infectious virus and extracellular viral RNA. Furthermore,compound 10, as well as a number of other analogues, inhibited HCV replication to some extent. However,there was no direct correlation between anti-BVDV and anti-HCV activity. Thus, the acridone scaffold,when appropriately functionalized, can yield compounds with selective activity against pestiviruses andrelated viruses such as the HCV.
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