| Abstract
| - Identification of new molecular scaffolds structurally unrelated to known antimalarials may represent a valid strategy toovercome resistance of P. falciparum (Pf) to currently available drugs.We describe herein the investigation of a new polycyclic pharmacophore, related to clotrimazole, to develop innovative antimalarial agents.This study allowed us to discover compounds characterized by a highin vitro potency, particularly against Pf CQ-resistant strains selectivelytargeting free heme, which are easy to synthesize by low-cost syntheticstrategies.
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