| Abstract
| - Following the characterization of polyoxypregnane esters andesterified glycosides from theless polar extracts of Leptadenia hastata, 34 new congenershave been isolated from the morepolar extracts. They possess sarcostin or deacetylmetaplexigeninas the aglycons and acetyl,benzoyl, cinnamoyl, nicotinoyl, and m-hydroxybenzoylresidues as the ester moieties linked atC-12 and/or C-20 of the aglycons. The oligosaccharide moietylinked to C-3 of the aglyconswas made up of three to five2,6-dideoxy-3-O-methylpyranoses,6-deoxy-3-O-methylpyranoses,or glucose. Their structures have been elucidated on the basis ofspectral evidence. Glycosideswith more complex oligosaccharidic chains were tested for theirantitumor activity on Rajicells.
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