| Abstract
| - Submerged liquid cultures of the basidiomyceteFavolaschia pustulosa (Xenova culturecollectionno. X27732) afforded the novel 9-methoxystrobilurin derivatives,9-methoxystrobilurin L (1)and 9-methoxystrobilurin E (2), and the related oudemansinderivative, oudemansin L (3).Their structures were established by 2D NMR experiments.Compounds 1 and 3 possess anovel arrangement of two isoprenoid units fused to the aromaticnucleus. Both 1 and 2 havethe E,E,E-configuration in thepentadienyl side chain as reported previously for9-methoxystrobilurins. Compound 1 was cytotoxic to cells of thehuman B lymphoblastoid cell line (Jijoye),with an IC50 of 1.8 nM. This cytotoxicity was observedin a 5- day assay only and was notapparent after 2 days. Compound 1 showed someantibacterial activity against Bacillussubtilis(MIC = 0.9 μM) and antifungal activity against Candidaalbicans (MIC = 6 μM).
|
