| Abstract
| - From a tryptophan metabolic study, 3-(hydroxyacetyl)indole,indole-3-carboxaldehyde, ando-aminobenzoic acid were obtained as tryptophan metabolitesfrom a staurosporine (1) producer,Streptomyces staurosporeus. A new tryptaminemetabolite,(3aR,8aS)-1-acetyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-3a-ol(2), was isolated along withNb-acetyltryptamine using S.staurosporeus fed with tryptamine. The unusual compound2 was proposed as a furthermetabolite of Nb-acetyltryptamine through anenzymatic oxidative cyclization. Examinationof the metabolites from the feeding of 5- and 6-fluorotryptamines usingthe same microorganismafforded the two novel compounds 3 and 4 as the5- and 6-fluoro derivatives of 2. However,5-hydroxytryptamine failed to generate the 5-hydroxy derivative of2. Indole-ring-substitutedmetabolites of staurosporine (1) were notobserved.
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