| Abstract
| - Bioassay-directed fractionation of the methyl ethyl ketone extractof Chiloscyphus rivularisyielded five new sesquiterpenes, 12-hydroxychiloscyphone(2), chiloscypha-2,7-dione (3), 12-hydroxychiloscypha-2,7-dione (4), chiloscypha-2,7,9-trione(5), and rivulalactone (6) inadditionto the known sesquiterpenes, 4-hydroxyoppositan-7-one (7),chiloscyphone (1), and isointermedeol (8). The structure and stereochemistry ofrivulalactone, a novel trinorsesquiterpene,was confirmed by its synthesis starting from 1.Compound 2 showed selective bioactivity inour yeast-based DNA-damaging assay and cytotoxicity to human lungcarcinoma cells.
|
