A new bromopyrrole alkaloid (1) along with (±)-2 and (±)-longamide (3) has been isolated from theJapanese marine sponge Homaxinella sp. The structures of the compounds were proposed on the basisof spectroscopic data. The optical resolution of (±)-2 by chiral HPLC was successful and afforded thetwo enantiomers, (+)-2 and (−)-2.