| Abstract
| - Aqueous methanol extracts from the bulbs of Hyacinthusorientalis were subjected to variousion-exchange column chromatographic steps to give2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine (DMDP) (1),2,5-dideoxy-2,5-imino-dl-glycero-d-manno-heptitol(homoDMDP) (2),2,5-imino-2,5,6-trideoxy-d-manno-heptitol(6-deoxy-homoDMDP) (3), 2,5-imino-2,5,6-trideoxy-d-gulo-heptitol (4),1-deoxynojirimycin (5), 1-deoxymannojirimycin(6), α-homonojirimycin(7), β-homonojirimycin (8),α-homomannojirimycin (9), β-homomannojirimycin(10), and 7-O-β-d-glucopyranosyl-α-homonojirimycin (MDL 25,637)(11). The structures of the new naturalproducts 3 and 4 were determined by spectroscopicanalysis, including extensive 1D and 2DNMR studies. Compound 2 was found to be a potentinhibitor of bacterial β-glucosidase,mammalian β-galactosidases, and mammalian trehalases, while3 was a potent inhibitor ofrice α-glucosidase and rat intestinal maltase. Compound4 was observed to be a good inhibitorof α-l-fucosidase.
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