Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resultedin the first isolation of roridin E acetate (5) from nature together with four common macrocyclictrichothecene isomers (1−4). Trichothecenes 1−5, while known as mycotoxins, were evaluated for theirhigh antimalarial activity.
