| Abstract
| - Two known cembrane diterpenes, flaccidoxide (1) and (1Z,3E,7E,11S,12S,14S)-11,12-epoxy cembra-1,3,7-trien-14-ol (2), and the new cembrane diterpene flaccidoxide-13-acetate (3) were isolated from specimensof Cladiella kashmani collected off Ponto do Oura, Mozambique. The modified Mosher's method establishedthe previously unassigned absolute configuration of 1 as (1Z,3E,7E,11S,12S,13S,14R)-14-acetoxy-11,12-epoxy cembra-1,3,7-trien-13-ol. Acetylation of 1 yielded 3 and thus confirmed the structure of 3 as(1Z,3E,7E,11S,12R,13S,14R)-13,14-diacetoxy-11,12-epoxy cembra-1,3,7-triene. All three diterpenes weretoxic to the brine shrimp Artemia salina.
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