| Abstract
| - Three new triterpenoids, 3α,27-dihydroxylup-20(29)-en-28-oic acid methyl ester, 3α-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3α-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, wereisolated from the roots of Peganum nigellastrum along with four known lupene-type triterpenoids. Thestructures of the new triterpenoids were determined by NMR spectroscopic means. The new triterpene,3α,27-dihydroxylup-20(29)-en-28-oic acid methyl ester is a DNA topoisomerase II inhibitor (IC50 = 8.9μM/mL).
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