| Abstract
| - Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4),and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygiumhypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1−5 were elucidatedby spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated.Triptonine B (2) demonstrated potent anti-HIV activity with an EC50 value of <0.10 μg/mL and an invitro therapeutic index value of >1000.
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